Modeling Case Studies:
Quantitative constraint screens for complex physical claims, mechanisms, and inverse problems
Constraint Screening an Extraordinary Geophysical Claim
I publish the methodology, assumptions, equations, uncertainty treatment, validation checks, and results of my independent research in technical reports.
My working notebooks, preprocessing pipelines, helper functions, and visualization code are part of my internal research workflow and are not publicly released.
When these assets are developed as part of a client project, the agreed-upon deliverables, including notebooks, preprocessing workflows, helper functions, and visualization tools, are provided to the client in accordance with the written project scope and applicable licensing terms.
As portions of the work receive external technical review, I will identify which analyses were reviewed and acknowledge the reviewers in the corresponding reports, with their permission.
Research Publication Policy
Selected Peer-Reviewed Publications & Technical Work
The predictive edge: modeling and simulation in drug product development, Advanced Drug Delivery Reviews, 2026
Shows my ability to evaluate and connect multiple modeling approaches across a complex development system. The work examines how mechanistic, statistical, hybrid, and AI-driven models can be used to screen options, identify risk, guide experiments, and support decisions from formulation design through commercialization.
A novel architecture for achieving high drug loading in amorphous spray dried dispersion tablets, International Journal of Pharmaceutics, 2020
Shows my experience designing around competing physical constraints. This work separated the functions of amorphous-drug stabilization, supersaturation maintenance, and manufacturability, then recombined them into a dosage-form architecture that reduced tablet mass by 40% while preserving performance.
Mechanisms of water permeation and diffusive API release from stearyl alcohol and glyceryl behenate modified release matrices, International Journal of Pharmaceutics, 2020
Shows my ability to separate competing physical mechanisms using data and modeling. This work linked measurable transport properties—wetting rate, diffusion coefficient, porosity, and matrix permeability—to observed drug-release behavior, identifying different rate-limiting processes in two lipid formulations.
Approximately 120 hours of quantitative analysis answering the question: What energy, torque, and impulse does a 104º crustal displacement require?